A safe and comfortable place to live/work can breed complacency. It is also the best place to try risky new things we would not otherwise contemplate - such as starting a new business, learning a new skill or developing an interest to a greater depth.
We can move to a new place to live -an exotic new city or country. Work won't need to be exciting then. (And perhaps shouldn't be so to avoid stress overload?) A familiar job description in a routine to balance out the adventure of living in a new place.
Extremophiles of course can go for broke on both fronts. New career, new country, new everything.
Life is short and YOLO right? But the familiar couch is so soporifically comfy...